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 The first mechanism of action of bm-MSC related to remyelination is the activation of the jak|stat3 pathway, which regulates the development of dorsal root ganglia.357 BM-MSCs have been reported to secrete vascular endothelial growth factor-a (vegf-a), neurotrophic factor brain (bdnf), interleukin-6|six, and leukemia inhibitor factor (lif), used for <a href=https://StemCellTherapyInCanada.com/>https://StemCellTherapyInCanada.com</a>, what directly participate in neurogenesis and neurite growth.357 vegf-a is the most important regulator of hemangiogenesis during development and bone homeostasis.